Adult

Aztreonam with avibactam

General Information

Monobactam and beta-lactamase inhibitor antibiotic

In patients with a history of penicillin or cephalosporin allergy, aztreonam may be administered without prior testing unless there is a history of ceftazidime allergy where allergy testing would be required. 

Restricted formulary antimicrobial: For details see OUH netFormulary

AWaRe antibiotic classification: All indications to be discussed with Micro/ID. Has not been classified in 2025 UK modified AWaRe list.

 

Note: There is an EPR powerplan associated with this drug. 

For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).

Standard dose

  Intravenous dose
Standard dose

Loading dose:  2.7g (2g aztreonam / 677mg avibactam) single dose 

followed 6 hours later by

Maintenance dose: 2g (1.5g aztreonam / 500mg avibactam) QDS
  • Each vial contains 1.5g aztreonam + 0.5g avibactam
  • Standard maintenance dose of 2g (1.5g aztreonam + 0.5g avibactam) is 1 vial

Obesity

No dose adjustment required.

Renal and hepatic impairment

Renal impairment

Creatinine Clearance (mL/min)* Dose
51 and above

Dose as in normal renal function
30 - 50

Loading dose: 2.7g (2g aztreonam / 677mg avibactam) single dose

followed 6 hours later by

Maintenance dose: 1g (750mg aztreonam / 250mg avibactam) QDS
16 - 29

Loading dose: 1.8g (1.35g aztreonam / 450mg avibactam) single dose

followed 8 hours later by

Maintenance dose: 900mg (675mg aztreonam / 225mg avibactam) TDS

15 or less

and on HD/HDF/High flux or PD

 Discuss with pharmacy

*dose ranges use creatinine clearance, rather than eGFR

 

Hepatic impairment

No dose adjustment required.

References

  1. Pfizer Limited. Summary of Product Characteristics (SPC). Emblaveo 1.5 g/0.5 g powder for concentrate for solution for infusion. Last revision of the text: 03/2025. Accessed via www.medicines.org.uk Accessed 08/09/2025
  2. BNF online accessed via www.medicinescomplete.com Accessed 08/09/2025
  3. The Renal Drug Database. EMBLAVEO (aztreonam/avibactam sodium). [online]. Last updated: 27/05/2025. Accessed via https://renaldrugdatabase.com Accessed 08/09/2025

Editorial Information

Last reviewed: 30 Sept 2025

Next review date: 01 Sept 2028

Author(s): AMST.