Caspofungin
General Information
Echinocandin
Restricted formulary antimicrobial: For details see OUH netFormulary
For all information regarding contra-indications, interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Standard dose
| Caspofungin IV dose | |
| Body weight up to 80 kg |
Loading dose: 70mg iv od for 1 day Maintenance dose: 50mg iv od |
|
Body weight 80kg or more |
Loading dose: 70mg iv od for 1 day Maintenance dose: 70mg iv od |
| Patient also taking enzyme inducers* (Regardless of weight) |
Loading dose: 70mg iv od for 1 day Maintenance dose: 70mg iv od |
| Moderate hepatic impairment (Child-Pugh score 7 to 9) (Regardless of weight) |
Loading dose: 70mg iv od for 1 day Maintenance dose: 35 mg iv od |
*Phenytoin, carbamazepine, dexamethasone and rifampicin. This list is not exhaustive, check BNF and SPC for interactions.
Obesity
Discuss with Micro/ID or AMS pharmacy team.
Renal and hepatic impairment
Renal impairment
No dose adjustment necessary
Hepatic impairment
| Caspofungin dose | |
| Mild hepatic impairment (Child-Pugh score 5 to 6) | No dosage adjustment is needed |
| Moderate hepatic impairment (Child-Pugh score 7 to 9) |
Loading dose: 70mg iv od for 1 day Maintenance dose: 35 mg iv od |
| Severe hepatic impairment (Child-Pugh score greater than 9) | Avoid (no data available) |
Additional information
The OUH Antifungal Patient Information Leaflet can be found HERE
References
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Flynn Pharma Ltd. Summary of product characteristics. Caspofungin 70mg powder for concentrate for solution for infusion. [online]. Last revision of the text: 6/1/23. Accessed via: https://www.medicines.org.uk/emc#gref Accessed: 23/3/25.
- Flynn Pharma Ltd. Summary of product characteristics. Caspofungin 50mg powder for concentrate for solution for infusion. [online]. Last revision of the text: 6/1/23. Accessed via: https://www.medicines.org.uk/emc#gref Accessed: 23/3/25.
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The Renal Drug Database. Caspofungin. Last revision of the text: 24/9/24. Accessed via renaldrugdatabase.com Accessed: 23/3/25.
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Sanford Guide. Caspofungin [Internet] Last revision of the text: 3/2/25
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Sanford Guide. Obesity dosing adjustment [Internet] Last revision of the text: 23/2/25
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British National Formulary. Caspofungin. Available via https://bnf.nice.org.uk/drug/caspofungin.html Accessed: 23/3/25.