Adult

Cefepime with enmetazobactam (Exblifep®)

General Information

A cephalosporin and beta-lactamase inhibitor.

Do NOT use if patient has a history of severe penicillin allergy.  If in doubt, discuss with Micro/ID.

Restricted formulary antimicrobial: For details see OUH netFormulary

AWaRe antibiotic classification: All indications to be discussed with Micro/ID. Has not been classified in 2025 UK modified AWaRe list.

For all information regarding contra-indications, interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).

Standard dose

  Intravenous dose
Standard dose

2.5g (2g cefepime/0.5g enmetazobactam)

TDS
  • Each vial contains 2g cefepime + 0.5g enmetazobactam
  • Standard dose of 2.5g (2 g cefepime + 0.5g enmetazobactam) is 1 vial

Note: The duration of infusion varies with indication, see SPC.

Renal and hepatic impairment

Renal impairment  

 

Creatinine Clearance  (mL/min)*

Dose 

Frequency

60 or over

Where creatinine clearance is over 150 ml/minute (augmented renal clearance), give infusion over 4 hours.

 Dose as in normal renal function

30-59

1.25 g

 

(1g cefepime/ 250 mg enmetazobactam)

 

TDS

15-29

1.25 g

 

(1g cefepime/ 250 mg enmetazobactam)

 

BD

Less than 15

1.25 g

 

(1g cefepime/ 250 mg enmetazobactam)

 

OD

HD/HDF/High flux/PD

Discuss with pharmacy

*Dose ranges use creatinine clearance, rather than eGFR

 

Hepatic impairment

No dose adjustment required


References

  • ADVANZ Pharma. EXBLIFEP 2 g/0.5 g powder for concentrate for solution for infusion summary of product characteristics. Electronic Medicines Compendium. Last revision of the text: 4/4/24 Available at  https://www.medicines.org.uk/emc Accessed: 2/3/26
  • British National Formulary. Cefepime-Enmetazobactam. Accessed via: BNF online accessed via www.medicinescomplete.com. Accessed 2/3/26
  • Sanford Guide [online]. Cefepime-Enmetazobactam. Last updated 31/10/25. Accessed 2/3/26
  • The Renal Drug Database. EXBLIFEP (cefepime hydrochloride and enmetazobactam). Last reviewed: 19/06/25. Available at: https://www.renaldrugdatabase.com Accessed 2/3/26

Editorial Information

Last reviewed: 04 Mar 2026

Next review date: 01 Mar 2029

Author(s): AMST.