Cefiderocol
General Information
Siderophore cephalosporin antibiotic
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Reserve'. All indications to be discussed with Micro/ID.
For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Dosing
| Intravenous dose | |
|
Standard dose |
2g TDS |
|
Augmented renal clearance with CrCL of 120 mL/min or more |
2g QDS* |
*QDS dosing can contribute a large sodium load if the dose is administered in sodium chloride 0.9% infusion fluid. Consider choice of infusion fluid when dosing QDS.
Renal and hepatic impairment
Renal impairment
|
Creatinine clearance** (mL/min) |
Intravenous dose |
|
120 and above |
Dose as in augmented renal clearance |
|
60-119 |
Dose as in normal renal function |
|
30-59 |
1.5g TDS |
|
15-29 |
1g TDS |
|
Less than 15 |
1g BD |
|
HDF/High flux/PD |
Dialysed; give post-dialysis on dialysis days Dose as in CrCl less than 15 mL/min |
**dose ranges use creatinine clearance, rather than eGFR
Note: Doses are based on Renal Drug Database
Hepatic impairment
No dose adjustment required.
References
- Shionogi. Fetcroja 1 g powder summary of product characteristics. Electronic medicines compendium. Last revision of the text 01/03/24. Accessed via www.medicines.org.uk Accessed 20/3/26.
- British National Formulary. Cefiderocol. BNF online accessed via www.medicinescomplete.com Accessed 20/3/26.
- The Renal Drug Database. Cefiderocol. Last updated 31/10/23. Accessed via https://renaldrugdatabase.com Accessed 20/3/26.
- Sanford Guide [online]. Cefiderocol. Last updated 13/3/26. Accessed via https://webedition.sanfordguide.com. Accessed 20/3/26.