Cefixime
General Information
Third generation cephalosporin antibiotic
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.
For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Standard Dose
| Oral dose | |
| Standard dose | 200mg-400mg OD* |
*Total daily dose can be given in two divided doses
Renal and hepatic impairment
Renal impairment
|
Creatinine clearance (mL/min)** |
Oral dose |
|
10 and above |
Dose as in normal renal function |
|
Less than 10 |
200mg OD |
|
HDF/High Flux |
Unknown dialysability Dose as in CrCl less than 10mL/min |
|
PD |
Not dialysed Dose as in CrCl less than 10mL/min |
**dose ranges use creatinine clearance, rather than eGFR
Note: Doses are based on Renal Drug Database
Hepatic impairment
No dose adjustment required
References
- ADVANZ Pharma. Suprax 200mg Tablets summary of product characteristics. Electronic medicines compendium. Last revision of the text 03/2024. Accessed via www.medicines.org.uk Accessed 23/3/26.
- British National Formulary. Cefixime. BNF online accessed via www.medicinescomplete.com Accessed 23/3/26.
- The Renal Drug Database. Cefixime. Last updated 7/7/23. Accessed via https://renaldrugdatabase.com Accessed 23/3/26.
- Sanford guide [online]. Cefixime. Last updated 13/3/26. Accessed via https://webedition.sanfordguide.com Accessed 23/3/26