Cefoxitin
General Information
Second generation cephalosporin antibiotic
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.
For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Standard dose
| Intravenous dose | |
| Standard dose |
2g every 4-6 hours (maximum 12g per day) |
Renal and hepatic impairment
Renal impairment
|
Creatinine clearance (mL/min)* |
Dose |
|
51 and above |
Dose as in normal renal function |
|
30-50 |
2g BD-TDS |
|
10-29 |
2g OD-BD |
|
5-9 |
2g loading dose then 500mg-1g OD-BD |
|
Less than 5 |
2g loading dose then 500mg-1g every 24-48 hours |
|
HD/HDF/High Flux |
2g OD Dialysed; give after dialysis |
|
PD |
1g OD Not dialysed |
*dose ranges use creatinine clearance, rather than eGFR
Hepatic impairment
No dose adjustment required
References
- Renascience Pharma Ltd. Renoxitin 1g Powder for solution for Injection or Infusion summary of product characteristics. Electronic medicines compendium. Last revision of the text: 14/5/25. Accessed via www.medicines.org.uk. Accessed 5/3/26
- The Renal Drug Database. Cefoxitin Sodium. Last updated 31/10/23. Accessed via https://renaldrugdatabase.com Accessed 5/3/26
- British National Formulary. Cefoxitin. BNF online accessed via www.medicinescomplete.com Accessed 5/3/26
- Sanford guide [online]. Cefoxitin. Last updated 23/1/26. Accessed via https://webedition.sanfordguide.com Accessed 5/3/26