Ceftaroline fosamil
General Information
Fifth generation cephalosporin antibiotic
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Reserve'. All indications to be discussed with Micro/ID.
For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Standard Dose
| Intravenous dose | |
| Standard dose | 600mg BD |
Note: Micro/ID may recommend 600mg iv TDS for specific patients
Obesity
No dose adjustment required
Renal and hepatic impairment
Renal impairment
|
Creatinine clearance (mL/min)* |
Where usual dose would be 600mg BD |
Where usual dose would be 600mg TDS |
|
Over 50 |
Dose as in normal renal function |
|
|
30-50 |
400mg BD |
400mg TDS |
|
15-30 |
300mg BD |
300mg TDS |
|
Less than 15 |
200mg BD |
200mg TDS |
|
HDF/High Flux/PD |
Dialysed; give post-dialysis on dialysis days Dose as in CrCl less than 15 mL/min |
|
*dose ranges use creatinine clearance, rather than eGFR
Hepatic impairment
No dose adjustment required
References
- Pfizer Limited. Zinforo 600 mg powder for concentrate for solution for infusion summary of product characteristics. Electronic medicines compendium. Last revision of the text 09/2025. Accessed via www.medicines.org.uk Accessed 20/3/26.
- British National Formulary. Ceftaroline fosamil. BNF online accessed via www.medicinescomplete.com Accessed 20/3/26.
- The Renal Drug Database. Ceftaroline fosamil. Last updated 14/8/23. Accessed via https://renaldrugdatabase.com Accessed 20/3/26.
- Sanford Guide [online].Ceftaroline. Last updated 13/3/26. Accessed via https://webedition.sanfordguide.com Accessed 20/3/26