Ceftazidime
General Information
Third generation cephalosporin antibiotic
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.
For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Dosing
| Intravenous dose | |
|
Standard dose |
1g TDS |
| Higher dose* | 2g TDS |
| OPAT regimen** | 3g BD |
Note: If patient is over 80 years of age the usual daily maximum dose is 3g; this can be increased to 6g daily on advice documented by Micro/ID
*Higher doses are indicated for CNS infections and Pseudomonas aeruginosa infections such as neutropenic sepsis, necrotising otitis externa (NOE), bronchiectasis, diabetic foot infection
**OPAT regimen to be advised by Micro/ID only
Obesity
Use upper end of dosing range
Renal and hepatic impairment
Renal impairment
|
Creatinine clearance (mL/min)*** |
Where usual dose would be 1g TDS |
Where usual dose would be 2g TDS or 3g BD |
|
51 and above |
Dose as in normal renal function |
|
|
31 - 50 |
1g BD |
2g BD (over 80 years usual daily maximum of 3g) |
|
16-30 |
1g OD |
2g OD |
|
6-15 |
500mg OD |
1g OD |
|
Less than 5 |
500mg every 48 hours |
1g every 48 hours |
|
HDF/High Flux |
Discuss with pharmacy |
|
|
PD
|
Dialysed 500mg OD |
Dialysed 1g OD |
***dose ranges use creatinine clearance, rather than eGFR
Note: Doses are based on Renal Drug Database
Hepatic impairment
- No dose adjustment required
- Severe hepatic impairment: Lack of data therefore close clinical monitoring for safety and efficacy is advised.
References
- Wockhardt UK Ltd. Ceftazidime 1g Powder for Solution for Injection or Infusion summary of product characteristics. Electronic medicines compendium. Last revision of the text 2/10/24. Accessed via www.medicines.org.uk Accessed 23/3/26.
- British National Formulary. Ceftazidime. BNF online accessed via www.medicinescomplete.com Accessed 23/3/26.
- The Renal Drug Database. Ceftazidime. Last updated 8/8/23. Accessed via https://renaldrugdatabase.com Accessed 23/3/26.
- All-Wales Antimicrobial Pharmacists’ Group (2022) Antimicrobial dosing in extremes of body weight in adults. Accessed 23/3/26.
- Sanford guide [online]. Ceftazidime. Last updated 13/3/26. Accessed via https://webedition.sanfordguide.com Accessed 23/3/26
- European Committee on Antimicrobial Susceptibility Testing. Breakpoint Tables for Interpretation of MICs and zone diameters. Last updated 1/1/26. Accessed via https://www.eucast.org/bacteria/clinical-breakpoints-and-interpretation/clinical-breakpoint-tables/ Accessed 12/3/26