Ceftazidime with avibactam (Zavicefta®)
General Information
Cephalosporin and beta-lactamase inhibitor antibiotic
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Reserve'. All indications to be discussed with Micro/ID.
Note: There is an EPR powerplan associated with this drug.
For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Standard Dose
| Intravenous dose | |
| Standard dose |
2g ceftazidime/0.5g avibactam (2.5g) TDS |
Each vial contains 2g ceftazidime + 0.5g avibactam
Standard dose of 2.5g is 2g ceftazidime + 0.5g avibactam which is 1 vial
Obesity
No dose adjustment required
Renal and Hepatic impairment
Renal impairment
|
Creatinine Clearance* (mL/min) |
Dose |
Frequency |
|
51 and above |
Dose as in normal renal function |
|
|
31-50 |
1g ceftazidime/0.25 g avibactam (1.25 g) |
TDS |
|
16-30 |
750 mg ceftazidime/187.5 mg avibactam (937.5 mg) |
BD |
|
6-15 |
750 mg ceftazidime/187.5 mg avibactam (937.5 mg) |
OD |
|
Less than 6 |
750 mg ceftazidime/187.5 mg avibactam (937.5 mg) |
every 48hours |
|
HDF/High flux/PD |
Dialysed; give post-dialysis on dialysis days Dose as in CrCl less than 6 mL/min |
|
*dose ranges use creatinine clearance, rather than eGFR.
Hepatic impairment
No dose adjustment required
References
- Pfizer Limited. Zavicefta 2g/0.5g powder for concentration for solution for Infusion summary of product characteristics. Electronic medicines compendium. Last revision of the text 08/2025. Accessed via www.medicines.org.uk. Accessed 3/2/26.
- British National Formulary. Ceftazidime-avibactam. Accessed via: BNF online accessed via www.medicinescomplete.com. Accessed 3/2/26.
- The Renal Drug Database. ZAVICEFTA (ceftazidime and avibactam sodium). Last updated 2/12/25. Accessed via https://renaldrugdatabase.com. Accessed 3/2/26.
- Sanford Guide [online]. Ceftazidime-avibactam. Last updated 30/1/26. Accessed via https://webedition.sanfordguide.com. Accessed 3/2/26.
- Sanford Guide [online]. Obesity dosing adjustment. Last updated 21/1/26. Accessed via https://webedition.sanfordguide.com. Accessed 3/2/26