Ceftazidime with avibactam (Zavicefta®)
General Information
Cephalosporin and beta-lactamase inhibitor antibiotic
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Reserve'. All indications to be discussed with Micro/ID.
Note: There is an EPR powerplan associated with this drug.
For all information regarding contra-indications, interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Standard Dose
| Intravenous dose | |
| Standard dose |
2g ceftazidime/0.5g avibactam (2.5g) TDS |
Each vial contains 2g ceftazidime + 0.5g avibactam
Standard dose of 2.5g is 2g ceftazidime + 0.5g avibactam which is 1 vial
Obesity
No dose adjustment required
Renal and Hepatic impairment
Renal impairment
|
Creatinine Clearance* (mL/min) |
Dose |
Frequency |
|
51 and above |
Dose as in normal renal function |
|
|
31-50 |
1g ceftazidime/0.25 g avibactam (1.25 g) |
TDS |
|
16-30 |
750 mg ceftazidime/187.5 mg avibactam (937.5 mg) |
BD |
|
6-15 |
750 mg ceftazidime/187.5 mg avibactam (937.5 mg) |
OD |
|
Less than 6 |
750 mg ceftazidime/187.5 mg avibactam (937.5 mg) |
every 48hours |
|
HDF/High flux/PD |
Dialysed; give post-dialysis on dialysis days Dose as in CrCl less than 6 mL/min |
|
*dose ranges use creatinine clearance, rather than eGFR.
Hepatic impairment
No dose adjustment required
References
- Pfizer Limited. Zavicefta 2g/0.5g powder for concentration for solution for Infusion summary of product characteristics. Electronic medicines compendium. Last revision of the text 08/2025. Accessed via www.medicines.org.uk. Accessed 3/2/26.
- British National Formulary. Ceftazidime-avibactam. Accessed via: BNF online accessed via www.medicinescomplete.com. Accessed 3/2/26.
- The Renal Drug Database. ZAVICEFTA (ceftazidime and avibactam sodium). Last updated 2/12/25. Accessed via https://renaldrugdatabase.com. Accessed 3/2/26.
- Sanford Guide [online]. Ceftazidime-avibactam. Last updated 30/1/26. Accessed via https://webedition.sanfordguide.com. Accessed 3/2/26.
- Sanford Guide [online]. Obesity dosing adjustment. Last updated 21/1/26. Accessed via https://webedition.sanfordguide.com. Accessed 3/2/26