Clindamycin
General Information
Lincosamide
Formulary antimicrobial: Use in accordance with Trust guidelines.
AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.
For all information regarding contra-indications, interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Dosing
|
|
Oral dose |
Intravenous dose |
|
Standard dose |
450mg TDS |
450mg TDS |
|
Higher dose |
600mg TDS-QDS |
900mg TDS-QDS |
See also:
ante-natal and post-partum infections (including severe sepsis/septic shock) guidelines
Treatment of Pneumocystis jirovecii pneumonia (PJP) guideline
malaria guidelines
Obesity
Dose at the upper end of recommended ranges.
For patients with severe and/or deep-seated infection, discuss with Micro/ID.
Renal and hepatic impairment
Renal impairment
- No dose adjustment required in renal impairment.
- HDF/High Flux: Unknown dialysability.
- HD/PD: Not dialysed.
Hepatic impairment
- No dose adjustment required in hepatic impairment.
References
- Sandoz Limited. Clindamycin 150mg capsules summary of product characteristics. Electronic medicines compendium. Last revision of the text 4/11/24. Accessed via www.medicines.org.uk Accessed 23/3/26.
- ADVANZ Pharma. Clindamycin 150mg/ml Solution for Injection or Infusion summary of product characteristics. Electronic medicines compendium. Last revision of the text 20/9/23. Accessed via www.medicines.org.uk Accessed 23/3/26.
- British National Formulary. Clindamycin. BNF online accessed via www.medicinescomplete.com Accessed 23/3/26.
- The Renal Drug Database. Clindamycin Last updated: 28/10/24. Accessed via: https://renaldrugdatabase.com Accessed 23/3/26
- Sanford guide [online]. Clindamycin Last updated 13/3/26. Accessed via https://webedition.sanfordguide.com Accessed 23/3/26.
- United Kingdom Clinical Pharmacy Association. Drug Dosing in Extremes of Body Weight in Critically Ill Patients [Internet]. 2013; version 1.0 Accessed via https://www.scottishintensivecare.org.uk/uploads/2014-07-24-19-55-33-Drugdosingatextremesofbod-45662.pdf Accessed 23/3/26.
- Meng L, Mui E, Holubar MK and Deresinski SC. Comprehensive Guidance for Antibiotic Dosing in Obese Adults. Pharmacotherapy [Internet]. 2017 [cited 2026 Feb 09]; 37:1415-1431. Available from: https://accpjournals.onlinelibrary.wiley.com/doi/full/10.1002/phar.2023 Accessed 23/3/26.