Adult

Dapsone

General Information

Sulfonamide antibiotic

Restricted formulary antimicrobial: For details see OUH netFormulary

See local protocol(s) for further advice:

For all information regarding contra-indications, interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).

  • Contraindicated in severe G6PD deficiency. Use with caution in mild or moderate G6PD. Check G6PD activity before starting treatment.

Dosing

 

Oral dose

PJP (Pneumocystis jiroveci pneumonia) prophylaxis

100mg OD

Treatment of mild-moderate PJP (in combination with trimethoprim)

100mg OD

Renal and hepatic impairment

Renal impairment

  • No dose adjustment required.
  • HDF/High Flux/PD: Dialysed. Dose as in normal renal function.
  • In patients with a GFR less than 20 mL/min use with caution and monitor for side effects.

Hepatic impairment

  • Dosage should be reduced in the elderly where there is an impairment of hepatic function.

References

  1. Aurobindo Pharma - Milpharm Ltd. Dapsone 50mg Tablets summary of product characteristics. Electronic medicines compendium. Last revision of the text 13/8/26. Accessed via www.medicines.org.uk Accessed 30/9/26.
  2. The Renal Drug Database. Dapsone. Last updated 29/10/24. Accessed via https://renaldrugdatabase.com Accessed 30/9/26.
  3. British National Formulary. Dapsone. BNF online accessed via www.medicinescomplete.com Accessed 30/9/26.
  4. Sanford guide [online]. Dapsone. Last updated 8/9/26. Accessed via https://webedition.sanfordguide.com Accessed 30/9/26.

Editorial Information

Last reviewed: 30 Sept 2026

Next review date: 28 Sept 2029

Author(s): AMST.