Fluconazole
General Information
Triazole antifungal
Capsules and intravenous infusion are Formulary antimicrobials: Use in accordance with Trust guidelines.
Liquid and intravenous injection are Restricted formulary antimicrobials: For details see OUH netFormulary
For all information regarding contra-indications, interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Standard dose
See superficial candida infections and invasive candida infections for dosing information
Obesity
There is limited clinical data about dosing of fluconazole in obese patients. Case reports suggest that higher doses may be required in obese patients who are critically unwell, taking into consideration renal function.
Renal and hepatic impairment
Renal impairment
No dose adjustment in single dose therapy.
For multiple doses, see below:
|
eGFR (mL /min /1.73m2) |
Dose (IV and Oral) |
|
10 - 50 |
Normal loading dose then 50-100% of normal dose |
|
Less than 10 |
Normal loading dose then 50% of normal dose |
|
HD/HDF/High Flux |
50% of normal dose daily, OR, 100% of normal dose 3 times a week after dialysis and 50% of normal dose on non-HDF days. Dialysed; give after dialysis |
| PD |
Normal loading dose then 50% of normal dose Dialysed; give after dialysis. |
Hepatic impairment
Use with caution in patients with hepatic impairment and/or when used with other hepatotoxic drugs - monitor LFTs.
Additional information
The OUH Antifungal Patient Information Leaflet can be found HERE
References
- Aurobindo Pharma - Milpharm Ltd. Summary of Product Characteristics. Fluconazole 150mg capsules [online]. Last revision of the text: 1/3/24. Accessed via: www.emc.medicines.org.uk Accessed 23/3/25
-
ADVANX Pharma. Summary of Product Characteristics. EMC. Fluconazole 2mg/ml Solution for Infusion [online]. Last revision of the text:11/3/24. Accessed via: www.emc.medicines.org.uk Accessed 23/3/25
-
BNF online accessed via www.medicinescomplete.com Accessed 23/3/25
-
Renal Drug Database. Fluconazole. [Internet] Last revision of the text: 11/6/24. Accessed 23/3/25
-
Sanford Guide. Fluconazole. [Internet] Last revision of the text: 3/2/25. Accessed 23/3/25
-
Sanford Guide. Obesity dosing adjustment [Internet] Last updated: December 2024. Accessed 23/3/25
-
UK Teratology Information Service. Use of fluconazole in pregnancy [Internet]. Last updated: November 2024. Accessed 23/3/25
-
LactMed. Fluconazole [Internet] Last updated: October 2024.Accessed 23/3/25