Isavuconazole
General Information
Triazole antifungal
Restricted formulary antimicrobial: For details see OUH netFormulary
For all information regarding contra-indications, interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Standard dose
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IV or oral isavuconazole |
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Loading dose
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200mg every 8 hours for a total of 6 doses |
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Maintenance dose |
200mg od |
Obesity
No dose adjustment required.
Renal and hepatic impairment
Renal impairment
IV and oral: No dose adjustment required.
Hepatic impairment
IV and oral:
- Mild or moderate hepatic impairment (Child-Pugh Classes A and B): No dose adjustment required
- Severe hepatic impairment (Child-Pugh Class C): Isavuconazole has not been studied in this patient group. Use in these patients is not recommended unless the potential benefit is considered to outweigh the risks.
Therapeutic Drug Monitoring
Therapeutic Drug Monitoring is required see Therapeutic Drug Monitoring (TDM) for Antifungal Agents
Additional information
The OUH Antifungal Patient Information Leaflet can be found HERE
References
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Pfizer Limited. Summary of Product Characteristics.Cresembra 200mg powder for concentrate for solution for infusion [online]. Last revision of the text: 09/24. Accessed via: www.emc.medicines.org.uk Accessed 1/5/25
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Pfizer Limited. Summary of Product Characteristics.Cresembra 100mg hard capsules [online]. Last revision of the text: 09/24. Accessed via: www.emc.medicines.org.uk Accessed 1/5/25
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BNF online accessed via www.medicinescomplete.com Accessed 1/5/25
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The Renal Drug Database. Isavuconazole. [internet]. Last updated: 11/7/24. Accessed via: https://renaldrugdatabase.com Accessed 1/5/25
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Sanford Guide. Isavuconazonium sulfate [Internet] Last revision of the text: 7/4/25
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Sanford Guide. Obesity dosing adjustment [Internet] Last revision of the text: 25/4/25
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LactMed. Isavuconazole [Internet] Last updated 15th April 2024. Accessed 1/5/25