Adult

Minocycline

General Information

Tetracycline

Restricted formulary antimicrobial: For details see OUH netFormulary

AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.

For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).

Dosing

  Oral immediate-release tablet Oral modified-release capsule
Susceptible infections 100mg BD Not applicable
Acne 50mg BD 100mg OD

Renal and hepatic impairment

Renal impairment

  • Mild, moderate or severe renal impairment: No dose adjustment required.
    • Immediate-release preparation: Manufacturer recommends use with caution in severe renal-impairment
  • HDF/High Flux: Dose as in normal renal function. Unknown dialysability.
  • PD: Dose as in normal renal function. Not dialysed.
  • Patients with complete renal failure: Immediate-release and Modified- release preparations are contraindicated

Hepatic impairment

  • No dose adjustment required
  • Use with caution in patients with hepatic impairment or those receiving potentially hepatotoxic drugs.

References

  1. Viatris Products Limited. Minocin MR 100 mg Modified Release Capsules summary of product characteristics. Electronic medicines compendium. Last revision of the text 10/2025. Accessed via www.medicines.org.uk Accessed 5/4/26
  2. Accord-UK Ltd. Minocycline Tablets BP 50mg summary of product characteristics. Last revision of the text 11/12/24. Accessed via https://products.mhra.gov.uk Accessed 5/4/26
  3. The Renal Drug Database. Minocycline. Last updated 28/10/24. Accessed via https://renaldrugdatabase.com Accessed 5/4/26.
  4. British National Formulary. Minocycline. BNF online accessed via www.medicinescomplete.com Accessed 5/426.

Editorial Information

Last reviewed: 07 Apr 2026

Next review date: 06 Apr 2029

Author(s): AMST.