Adult

Streptomycin

General Information

Aminoglycoside

Unlicensed Non-Formulary antimicrobial:  Must be recommended/prescribed by a Micro/ID consultant or registrar.

AWaRe antibiotic classification: 'Other'. Use as per guidelines or Micro/ID advice.

For all information regarding contra-indications, interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).

Standard dose

See Streptomycin - TB DRUG MONOGRAPHS

Renal and hepatic impairment

Dose in renal impairment

Discuss with Micro/ID or pharmacy

 

Dose in hepatic impairment

Discuss with pharmacy. A dose reduction is not usually required but the product information provided with the Unlicensed Medicine will need to be reviewed to guide prescribing.

Therapeutic Drug Monitoring

See Streptomycin - TB DRUG MONOGRAPHS

MHRA Drug Safety Updates

MHRA Drug Safety Update (January 2021): Drug Safety update (January 2021) Aminoglycosides (gentamicin, amikacin, tobramycin, and neomycin): increased risk of deafness in patients with mitochondrial mutations.

References

  1. Sanford guide [online]. Streptomycin. Last updated 8/9/26. Accessed via https://webedition.sanfordguide.com Accessed 30/9/26

Editorial Information

Last reviewed: 30 Sept 2026

Next review date: 02 Mar 2026

Author(s): AMST.