Adult

Tigecycline

General Information

Glycylcycline

Restricted formulary antimicrobial: For details see OUH netFormulary

AWaRe antibiotic classification: 'Reserve'. All indications to be discussed with Micro/ID.

For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).

Standard Dose

  Intravenous dose
Standard dose

Loading dose: 100mg single dose

followed 12 hours later by

Maintenance dose: 50mg BD

Obesity

No dose adjustment usually required.

In morbidly obese patients with multi-drug resistant infections: Higher doses may be required, discuss with Micro/ID.

Renal and hepatic impairment

Renal impairment

  • No dose adjustment required.
  • HDF/High Flux - Dose as in normal renal function. Unknown dialysability.
  • PD - Dose as in normal renal function. Not dialysed.

 

Hepatic impairment

  • Mild and moderate hepatic impairment: No dose adjustment required.
  • Severe hepatic impairment (Child- Pugh Class C): Use with caution. Give 100mg loading dose followed by 25mg BD. 

References

  1. Pfizer Limited. Tygacil 50mg powder for solution for infusion summary of product characteristics. Electronic medicines compendium. Last revision of the text 09/2025. Accessed via www.medicines.org.uk Accessed 5/4/26
  2. The Renal Drug Database. Tigecycline. Last updated 18/11/24. Accessed via https://renaldrugdatabase.com Accessed 5/4/26.
  3. British National Formulary. Tigecycline. BNF online accessed via www.medicinescomplete.com  Accessed 5/4/26
  4. Sanford Guide [online]. Tigecycline. Last updated 31/3/26. Accessed via https://webedition.sanfordguide.com Accessed 5/4/26
  5. All-Wales Antimicrobial Pharmacists’ Group (2022) Antimicrobial dosing in extremes of body weight in adults. Accessed 5/4/26.

Editorial Information

Last reviewed: 07 Apr 2026

Next review date: 05 Apr 2029

Author(s): AMST.