AHAH: Skin & Soft Tissue Infections
Cellulitis
Duration: 5 days
Antibiotic Regimens:
|
Route |
Antibiotic and Dosage |
Notes |
|
Oral (Preferred) |
flucloxacillin 1g po QDS |
|
|
cefalexin 1g po TDS |
|
|
|
co-trimoxazole 960mg po BD |
Pause ACE inhibitors/Angiotensin receptor blockers or Potassium sparing diuretics |
|
|
doxycycline 100mg po BD |
Can also be 200mg po OD |
|
|
IV (Aim for rapid oral switch) |
cefazolin* 2g iv OD AND probenecid 1g po OD |
Probenecid is taken orally just before cefazolin is given. Be aware of interactions and dose adjustment in renal impairment |
|
Discuss with Micro/ID |
Options recommended by Micro/ID may include linezolid, teicoplanin, daptomycin or dalbavancin. |
*Caution: Prothrombin time, INR and APTT may increase on cefazolin treatment courses, please monitor. For more information see Cefazolin associated coagulation disorders
Diabetic Foot Infection
Consider referral to OCDEM for MDT discussion on management.
Duration: 5 days
Antibiotic Regimens:
Mild infection
|
Route |
Antibiotic and Dosage |
Notes |
|
Oral (Preferred) |
flucloxacillin 1g po QDS |
|
|
doxycycline 100mg po BD |
Can also be 200mg po OD | |
|
co-trimoxazole 960mg po BD |
Pause ACE inhibitors/Angiotensin receptor blockers or Potassium sparing diuretics |
Moderate infection
|
Route |
Antibiotic and Dosage |
Notes |
|
Oral (Preferred) |
co-trimoxazole 960mg po BD AND metronidazole 400mg po TDS |
Pause ACE inhibitors/Angiotensin receptor blockers or Potassium sparing diuretics |
|
doxycycline 100mg BD AND metronidazole 400mg po TDS |
Doxycycline can also be 200mg po OD | |
|
co-amoxiclav 625mg po TDS |
Avoid in patients with high frailty scores |
|
|
IV (Aim for rapid oral switch) |
co-trimoxazole 960mg iv BD AND metronidazole 400mg po TDS |
Pause ACE inhibitors/Angiotensin receptor blockers or Potassium sparing diuretics Metronidazole is oral |
|
co-amoxiclav 1.2g iv TDS |
Avoid in patients with high frailty scores |
Severe infection
Refer to inpatient guidelines.